Transforming our future by unlocking the power of DNA: the representation of health-related genomic testing in UK news items

Many people will have had no formal education on health-related genomic testing, so information from media sources may constitute a major influence in shaping ideas and expectations around genomic tests. We undertook a framing analysis of 186 UK news items discussing health-related genomic testing in the context of various recent UK-based initiatives: the 100,000 Genomes Project...

Modeling of complex physical and biological problems using bi-univalent function calculus

In recent years, bi-univalent functions and fractional calculus have attracted considerable attention due to their strong theoretical foundations and potential applications in applied sciences. However, most existing studies focus primarily on coefficient estimates from a purely theoretical perspective, with limited attention given to practical physical or biological...

Oxygen stoichiometry-driven charge compensation and Ruddlesden–Popper defects in ferromagnetic high-entropy manganite thin films

High-entropy oxides (HEOs) originate from an innovative materials design strategy that stabilizes single-phase solid solutions despite the inclusion of multiple principal elements into a single cation sublattice. While prior efforts have largely focused on cation disorder, the impact of anion defects on the structure and properties of HEOs remains unexplored. Here, we examine the...

Rhodoliths can act as daily resolution paleotemperature archives in the Red Sea

Long-term, high-frequency temperature records are critical for evaluating the vulnerability of marine ecosystems to ongoing ocean warming. Commonly used paleoceanographic archives, such as corals and bivalves, face regional and ecological constraints. Rhodoliths, free-living coralline red algal nodules, are established and globally accessible alternatives, yet their complex three...

Smartphone movement data can reliably predict smoking lapses and cravings to enable timely smoking cessation support

Decades of research aiming to develop effective smoking interventions have identified triggers that contribute to failed quitting attempts including environmental (e.g. location), social (presence of other smokers), or internal (e.g. stress). Here, it is shown for the first time that passively collected movement data from smokers’ smartphones’ sensors (accelerometer, gyroscope...

Konstruksi Brand Identity Produk Lokal: Studi Strategi Komunikasi Pemasaran Pemerintah Negeri Morella

Marketing communication strategy is an important element in business development, particularly in addressing the challenges of marketing local products. This study aims to examine the marketing communication strategies implemented by the Morella Village Government and Village-Owned Enterprises (BUMDES) in improving the marketing of Morella nutmeg juice products produced by local...

PEDAGOGICAL AND PSYCHOLOGICAL APPROACHES TO THE DEVELOPMENT OF SELF-ESTEEM IN PRESCHOOL CHILDREN

This article provides a theoretical analysis of pedagogical and psychological approaches to the development of self-esteem in children attending preschool educational institutions. The psychological essence of the concept of self-esteem, its role in the personal development of preschool children, and its relationship with social adaptation and future educational success are...

Sustainable high-throughput microwell spectrophotometric methods for avapritinib quality control via charge-transfer complexation

Avapritinib (AVA) is a breakthrough targeted therapy as the first potent inhibitor approved for gastrointestinal stromal tumors (GIST) with PDGFRA D842V mutations. It lacks convenient analytical methods for routine quality control. This study addresses this gap by developing and validating two novel, green, high-throughput microwell spectrophotometric methods (MW-SPMs) for AVA...

Author Correction: Biophysical prediction of protein–peptide interactions and signaling networks using machine learning

Pengaruh Kepemimpinan Transformasional dan Motivasi Terhadap Kinerja Guru Melalui Employee Engagement pada SMP di Kecamatan Tarogong Kaler Kabupaten Garut

Penelitian ini bertujuan untuk menganalisis pengaruh kepemimpinan transformasional dan motivasi terhadap kinerja guru dengan employee engagement sebagai variabel mediasi. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei terhadap 76 responden. Teknik analisis data yang digunakan adalah Structural Equation Modeling berbasis Partial Least Square menggunakan...

Comparison of ventilation with second-generation supraglottic airway devices in a prospective randomized cadaver study

Second-generation supraglottic airway devices (SADs) are widely used alternatives to endotracheal intubation in both anesthesia and emergency airway management. The newly developed LT®evo represents a redesigned version of the established Laryngeal Tube Suction Disposable (LTS-D). This study compared the ventilatory performance of the LT®evo with endotracheal intubation and three...

Islamic Tolerance as an Ethics of Coexistence in Muḥammad ʿImārah’s Thought

Debates on Islamic tolerance continue to turn on the relation between doctrinal conviction, freedom of conscience, and public coexistence in plural societies. This article examines how Muḥammad ʿImārah’s Al-Samāḥah al-Islāmiyyah constructs Islamic tolerance as coexistence ethics. Using directed qualitative content analysis, the study analyzes textual units concerning Qur'anic non...

Neodymium magnetic field meets nanocatalysis: a sustainable route to novel azines and condensed heterocycles

A sustainable and effective approach for manufacturing heterocyclic compounds was established utilizing Fe₃O₄ nanoparticles in the presence of a neodymium static magnetic field (about 9000 G). Pyrimidine, benzimidazole, quinoxaline, and benzodiazepine derivatives were swiftly synthesized at ambient temperature with excellent efficiency; no reaction transpired in the absence of a...

Genotype influences antidepressant discontinuation in a pre-emptive pharmacogenetic testing population

We performed a retrospective cohort study to evaluate risk of antidepressant discontinuation as a function of CYP2C19 and CYP2D6 phenotype. Patients who participated in an elective genomic screening and had a diagnosis of depression or anxiety with a corresponding antidepressant were analyzed. This resulted in 5 808 patients comprising 8 571 antidepressant orders. Of the total...

Author Correction: Acarbose redirects gut microbiome utilization of dietary carbohydrates to suppress anaphylaxis in mice

Correction: The effects of music and virtual reality on pain and anxiety during central venous port implantation: a randomised clinical trial

APPLICATION OF REPRESENTATIVES OF THE APIACEAE FAMILY IN PHARMACEUTICS AND MEDICINE

This article highlights the significance of plants belonging to the Apiaceae family in pharmaceuticals and folk medicine. Members of the lily family contain essential oils, flavonoids, alkaloids, vitamins, and other biologically active substances, which are widely used in the treatment and prevention of various diseases. The article analyzes the chemical composition and medicinal...

The Effect Of K3 On Employee Productivity Through Company Commitment And Culture: Systematic Literature Review (SLR) With Bibliometrics

This study aims to systematically analyze the influence of Occupational Safety and Health (K3) on employee productivity through organizational commitment and company culture using the Systematic Literature Review (SLR) approach. K3 has a strategic role in creating a safe and healthy work environment, which not only contributes to reducing the number of occupational accidents and...

Architectural and geotechnical aspects affecting earthquake resilience for the antique Egyptian Khufu pyramid

The Great Pyramid of Khufu, completed during Egypt’s Old Kingdom (2600–2450 BCE), exhibits the architectural expertise of ancient Pharaonic Egypt. To understand the structural longevity and earthquake resilience of this iconic monument, we carried out a comprehensive ambient noise survey employing horizontal-to-vertical spectral ratio (HVSR) analysis at 37 measurement points...

Field in the frame: an aerial view of greening Svalbard

Crowded Housing and Urban Residence as Risk Factors for Under-Five Children’s Pneumonia in Indonesia: Analysis of SSGI 2024 Data

Pneumonia remains the leading cause of morbidity and mortality among under-five children in Indonesia, with cases tending to increase each year. This study aimed to examine the association between crowded housing, cooking fuel type, nutritional status, sex, and classification of residence with the incidence of under-five children in Indonesia. This study used a cross-sectional...

A robust direction of arrival estimation method based on the chaotic MUSIC algorithm

This article proposes a robust direction of arrival (DOA) estimation method in which the traditional MUSIC algorithm is enhanced with the Tukey Biweight cost function. The proposed scheme is specifically designed to perform well in chaotic signal situations. The chaotic nature of real world signal environments is modeled using a chebyshev-based chaotic number generator, which...

Integrated torrefaction-anaerobic digestion of bamboo waste for enhanced energy recovery: process optimization, product characterization, and techno-economic evaluation

This study evaluates an integrated valorization pathway for bamboo waste that combines torrefaction and anaerobic digestion (AD) to recover energy from both solid and liquid process streams within a circular economy framework. Specifically, a dual-stream valorization approach is developed to maximize energy recovery from both bio-coal and torrefaction condensate. Bamboo’s high...

A neuronal basis for mental imagery

Human inflammatory bowel disease-on-a-chip for modelling disease progression, cancer initiation and sex-specific effects

Patients affected by inflammatory bowel disease (IBD) exhibit compromised intestinal barrier function and decreased mucus accumulation, as well as increased inflammation, fibrosis and cancer risk, with symptoms often being exacerbated in women during pregnancy. Here we replicate these IBD hallmarks in human-derived organ-on-a-chip devices lined by colon epithelial cells from...

Longitudinal evaluation of the psychometric stability of the somatic symptom scale-8 (SSS-8) in a large German general population sample

The Somatic Symptom Scale (SSS-8) is a brief 8-item tool for screening common somatic symptoms. This study is the first to examine its temporal invariance and stability across three COVID-19 pandemic time points, while also analyzing changes in SSS-8 scores in the general population and across groups (sex, age, relationship status, poverty status), and testing temporal stability...

The Impact of Being Fatherless on the Self-Concept of Girls

This study aims to analyze the impact of fatherlessness on the self-concept of girls in families. The research method uses a qualitative descriptive approach with a case study method. The research informants consisted of one girl as the primary subject and the mother as a supporting informant. Data collection techniques were carried out through in-depth interviews and...

Objective-function-guided automated VMAT planning reduces OAR dose, low-dose exposure, and inter-planner variability in breast radiotherapy

This study presents and evaluates an automated volumetric modulated arc therapy (VMAT) planning framework for breast cancer based on objective function value (OFV)–guided optimization. The primary objective is to systematically improve organ-at-risk sparing through automated and reproducible optimization of planning constraints while maintaining clinically acceptable target...

THE IMPORTANCE OF EMOTIONAL AND MORAL RESILIENCE IN TODAY’S DEMANDS

This article analyzes the role of emotional and moral resilience in human life and professional activity in the context of globalization and rapid information exchange. It also scientifically explains the relationship between emotional stability, moral values, and psychological adaptability of an individual. The study reveals the significance of emotional and moral resilience in...

Spheroids reveal hypoxia‑driven spatial restriction of adenoviral infection

Hypoxia is a hallmark of solid tumors and represents a major barrier for effective cancer therapies, including oncolytic virotherapy. While adenoviruses are widely studied as oncolytic agents, the impact of tumor-associated hypoxia on viral infection and spatial spread remains incompletely understood. Here, we investigated how oxygen availability influences adenovirus infection...