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Industrial waste for the production of fired clay bricks: an analysis of acoustic and mechanical properties
Fired clay bricks are made from red clays calcined at high temperatures, producing strength phases that are generally based on mullite. It is known that the use of industrial waste in fired clay bricks promotes sustainability, affecting properties such as strength, water absorption and porosity. In addition, industrial waste can improve the acoustic insulation of the blocks...
Ulnar lengthening for forearm deformities in hereditary multiple exostoses: a systematic review and meta-analysis (2015–2025)
Background Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder frequently associated with progressive forearm deformities, including ulnar shortening, radial bowing, and radial head dislocation. Ulnar lengthening using distraction osteogenesis has become the principal surgical strategy; however, outcomes, techniques, and complication profiles vary...
Modern Approaches to Teaching Pediatric and Adolescent Gynecology
Purpose of Review To examine global gaps in Pediatric and Adolescent Gynecology (PAG) education and assess how limited curricular exposure contributes to disparities in care. This review also explores emerging educational strategies, including simulation, virtual learning, and artificial intelligence, to strengthen PAG training. Recent Findings Despite its clinical importance...
The multiphase-field method based on internal state variables
The multiphase-field method is widely used to simulate the evolution of complex microstructures in computational materials science and is commonly derived via a variational approach. When coupled with heat conduction, it is desirable to derive both the multiphase-field method and the heat conduction equation from a unified, consistent framework. In the present work, this is...
A Latent Profile Analysis of Coping Strategies among Adolescent Cyberbullying Victims: Comparing the Roles of Online and Offline Social Capital
Cyberbullying victimization among adolescents is an escalating concern, necessitating deeper insights into coping strategies. This study aims to uncover distinct patterns of coping strategies and to examine how prior cyber-victimization, private information disclosure (self-disclosure, disclosure perpetration, disclosure victimization), and social capital (online and offline...
The changes in perceived self-efficacy, academic engagement, and empathy following simulation-based learning among undergraduate physiotherapy students: a quasi-experimental study
Background Physiotherapy (PT) education must foster both clinical competencies and non-technical skills such as communication, empathy, and self-efficacy to prepare students for professional practice. Simulation-Based Learning (SBL) offers a structured and safe environment to develop these skills. While the benefits of SBL have been documented in nursing and medical education...
Robotic surgery in colorectal emergencies: a systematic review of current evidence
Background Although laparoscopy continues to be the predominant minimally invasive approach in most emergency settings, the advantages of robotics, well established in elective surgery, are currently being explored in selected scenarios and specialized centres. Methods A systematic review was conducted using PubMed, Cochrane Library and Scopus databases until January 2025...
The impact of systemic corticosteroids guided by blood eosinophil thresholds and rome classification on clinical outcomes in hospitalized AECOPD patients: a multicenter study
Introduction This study assessed the efficacy of combining blood eosinophil (EOS) thresholds and Rome classification to guide corticosteroid therapy in hospitalized acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients. Methods This multicenter study analyzed data from 7 to 111 AECOPD patients, stratified by EOS counts (< 100, 100–300, > 300 cells/μL) and...
Cost-effectiveness of prehabilitation for elderly (pre-)frail patients prior to elective surgery compared to standard care - an economic evaluation from a societal perspective
Background Frailty syndrome is highly prevalent among elderly surgical patients, increasing their risk of experiencing perioperative complications and developing long-term disability. Prehabilitation may reduce these risks by optimising patients’ physiological reserves prior to surgery. The PRAEP-GO trial, a multicentre randomised controlled outcome assessor-blinded trial...
Real-World Characteristics and Treatment Patterns of Calcitonin Gene-Related Peptide Monoclonal Antibody Users: a Japanese Claims Database-Based Study
Introduction Understanding real-world calcitonin gene-related peptide monoclonal antibodies’ (CGRP mAbs) use in patients with migraine is necessary to potentially guide treatment strategies. Methods This retrospective cohort study analyzed administrative claims data from the IQVIA claims data for Japan. It included CGRP mAb-naïve individuals with confirmed migraine diagnosis and...
Enhancing the precision of clinical assessment in juvenile idiopathic arthritis through the JADAS
The use of composite disease activity scores enables a pragmatic approach to the measurement of the level of disease activity in children with juvenile idiopathic arthritis (JIA). These tools are constructed through the combination of individual measures and provide a quantification of the absolute level of disease activity in one summary number on a continuous scale. The first...
Social Comparison and the Vices of Pride: A Kierkegaardian Perspective
This article connects Kierkegaard’s warnings about social comparison to “vices of pride” such as self-righteousness, domination, presumption, vanity and hyper-autonomy. In Sect. 1, I stress the ways these vices use social comparison and show their connections with self-importance. In Sect. 2, I investigate Kierkegaard’s prima facie startling claim that “pride is cowardliness...
Cumulative stress hyperglycemia ratio exposure and dynamic trajectories reveal prognostic determinants of acute hyperlipidemic pancreatitis: an 5-year cohort study
Background The stress hyperglycemia ratio (SHR) and glycemic variability (GV) both reflect acute glycemic fluctuations, with established roles in cardiovascular and stroke diseases. However, their prognostic value in acute hyperlipidemic pancreatitis (HTG-AP) remains underexplored. Traditional assessments based on single measurements fail to capture the dynamic evolution...
The power of webinars: expanding diverse female representation and role models in surgery
Background Women, particularly those from widening participation (WP) backgrounds, remain underrepresented in surgical specialties. The educational pipeline is marked by limited exposure to relatable role models, which may discourage these individuals from pursuing surgical careers. Digital learning platforms offer a novel approach to address this gap. Methods In collaboration...
Detecting Patterns of Intimate Partner Violence Using Qualitative Analyses and Machine Learning Algorithms
Intimate partner violence (IPV) survivors increasingly use social media platforms to share their experiences and to seek help and support for their IPV-related concerns. IPV evidence extracted from social media platforms can provide valuable information and complement data obtained from conventional data sources (e.g., self-reports and interviews) thereby enhancing our...
Directional effects of typhoons on landslide susceptibility: an ensemble machine learning approach
This study covers the entire island of Taiwan, a region located in the Western North Pacific Ocean. The combination of steep terrain, fragile geology, and concentrated rainfall makes Taiwan highly prone to typhoon-induced landslides, posing significant threats to infrastructure, communities, and ecosystems. The research develops an ensemble machine learning framework to map...
The ecoepidemiology of cutaneous leishmaniasis in Ethiopia: a systematic review and meta-analysis
Background Cutaneous leishmaniasis (CL) is a neglected tropical skin disease. In Ethiopia, CL is a public health concern; about 29 million people are at risk, with an estimated incidence of up to 50,000 new cases annually. In endemic communities, access to diagnosis, treatment, and prevention is crucial but often limited. Understanding the prevalence and access to care, as well...
Clinical profile of benralizumab in severe eosinophilic asthma: a subgroup-driven meta-analysis
Background Severe eosinophilic asthma is associated with frequent exacerbations, decline in lung function, and impaired quality of life, posing significant challenges in clinical management. Benralizumab is a monoclonal antibody targeting the interleukin-5 receptor alpha subunit that rapidly depletes eosinophils via antibody-dependent cellular cytotoxicity. However, a systematic...
Idiotypic-susceptible Alzheimer’s disease: a clinically relevant, neurofibrillary tangle subtype
Neurofibrillary tangles in Alzheimer’s disease (AD) stereotypically spread from the medial temporal lobe to association areas and then to idiotypic areas (i.e., primary motor, somatosensory, auditory, and visual). Previous studies have reported variable and clinically relevant tangle densities across the hippocampus and association cortices, but the idiotypic tangle burden is...
Community structure of stream macroalgae in lotic ecosystems from highland grasslands in national parks of southeastern Brazil
Stream macroalgal communities were sampled at 58 sites across four national parks representing highland grasslands in southeastern Brazil. We assessed taxonomic beta diversity and its components (spatial turnover and nestedness), as well as the influence of selected environmental variables. Environmental conditions varied widely among streams from the different parks, reflecting...
A financial resource curse in the context of a small developing resource-based economy: The case of Suriname
Our study explores the impact of mineral resources on financial development in Suriname via a commodity-price-shock channel. Using a Structural VAR (SVAR) model and time series data from 1980 to 2021, we find evidence of a financial resource curse. More specifically, negative commodity price shocks undermine financial development by reducing bank lending and deposits...
Lactate-associated transcriptomic alterations and malignant phenotypes in colorectal cancer
Lactate, an energy source and metabolic by-product, has been implicated in cancer progression, but its role in colorectal cancer (CRC) remains incompletely understood. This study investigated the clinical significance, biological effects, and transcriptomic responses of CRC cells to lactate. In human CRC specimens, lactate levels were positively associated with advanced clinical...
Role of neuronal oscillations in memory driven visual processing
Background Successful working memory of previous locations is critical for optimal navigation of the environment in primates. However, it remains unclear how successful working memory influences the statistics of sensory-motor probing (e.g., whisking, sniffing, saccading). This study addresses this gap by investigating the coupling between saccadic eye movements and neural...
Exact and heuristic approaches for the integrated block relocation and fleet allocation problem with soft precedence constraints
We introduce the integrated block relocation and fleet allocation problem with soft precedence constraints, which jointly determines the unloading sequence of items and their assignment to a heterogeneous fleet of capacity-limited vehicles. The new problem aims at maximizing the number of delivered items while minimizing violations of a given item precedence order. Items with...
PENGEMBANGAN INSTRUMEN ASESMEN DIGITAL DIGIRATIO ASSESS BERBASIS PROBLEM SOLVING MENGGUNAKAN WAYGROUND PADA MATERI RASIO DAN PROPORSI DI SMP
The mathematical problem-solving ability of junior high school students in the topic of ratio and proportion remains relatively low, particularly in understanding contextual problems and constructing solution strategies. Meanwhile, the assessments commonly used by teachers have predominantly taken the form of conventional tests that emphasize final answers over students' thinking...